Martin Kriegel, MD, Ph.D.
Assistant Professor of Immunobiology and Rheumatology, Yale School of Medicine
The Kriegel lab is interested in understanding how genetics shape the microbiome, the collection of all microbes living on us. These microbes are needed for immune and metabolic functions of healthy people. Preliminary data from the Kriegel lab suggests that an alteration in an autoimmune-predisposing gene, that is known to contribute to type 1 diabetes, changes the composition of a group of gut microbes. It is speculated that the change in the gut microbial community in subjects that carry this genetic risk factor, leads to immune dysregulation. Kriegel plans to collaborate with Herold at Yale and colleagues at Jackson Laboratory to test if type 1 diabetes patients with this autoimmune predisposition harbor similar microbiome changes. If so, they want to study if the altered microbial communities in the gut affect certain immune cells to facilitate autoimmune destruction of the insulin-producing cells in the pancreas.
Prof. Alon Chen
Head, Department of Neurobiology, Weizmann Institute of Science
Dr. Yael Kuperman
The Sarah and Rolando Uziel Research Associate Chair, Assistant Staff Scientist Department of Veterinary Resources, Weizmann Institute of Science
Gerald I. Shulman
Professor of Medicine (Endocrinology) and Professor of Cellular and Molecular Physiology; Investigator, Howard Hughes Medical Institute; Co-Director, Yale Diabetes Research Center; Director, Yale Mouse Metabolic Phenotyping Center
Project: Chen, Kuperman and Shulman will exchange expertise and knowledge available at the Yale and Weizmann Institute Metabolic Phenotyping Centers and will resume past collaborations on the involvement of stress-signaling molecules, in both brain and muscle, in regulating metabolic functions and stress-induced metabolic diseases such as obesity, type-2 diabetes and eating disorders.
Prof. George Weinstock
Professor, Evnin Family Chair and Director of Microbial Genomics, Jackson Laboratory
Dr. Eran Elinav
The Rina Gudinski Career Development Chair, Weizmann Institute of Science
Kevan Herold, MD
Professor of Immunobiology and Internal Medicine, Yale School of Medicine
Project: Study on the microbiome and its role in obesity and metabolic syndrome.
Prof. George Weinstock of JAX and Dr. Eran Elinav will collaborate on a study of immunological and microbial contributions to obesity and the metabolic syndrome. Dr. Elinav, who completed his postdoctoral fellowship at Yale, is a physician-scientist (MD Ph.D.) and a member of the Weizmann Institute's Department of Immunology; his group studies the roles of microbiome-host immune interactions in health and disease. He is the incumbent of the Rina Gudinski Career Development Chair. Dr. Weinstock is Professor, Evnin Family Chair and Director of Microbial Genomics at JAX and former leader in the Human Genome Project, the Human Microbiome Project, and other large-scale applications of genomic technology. He received his Ph.D. from MIT and completed his postdoctoral fellowship at Stanford University Medical School.